Genetic modifiers of HbF and response to hydroxyurea in sickle cell disease

doi:10.1002/pbc.22754

Article

Genetic modifiers of HbF and response to hydroxyurea in sickle cell disease

9 Sept 2010

Abstract excerpt

Fetal hemoglobin (HbF) levels are generally inversely proportional to severity of sickle cell disease (SCD) for given sickle phenotypes. Molecular regulation of HbF occurs through complex interactions cis and trans to the beta globin gene locus. Novel insights made through population-based genetic epidemiologic studies of non-anemic populations were replicated in SCD groups, despite large differences in HbF...

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