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Discovering the genetics underlying foetal haemoglobin production in adults

6 Mar 2009

Abstract excerpt

Sickle cell disease (SCD) and beta thalassaemia, caused by lesions that affect the HBB (beta globin gene), form the most common human genetic disorders world-wide, and represent a major public health problem. Inter-individual variation in foetal haemoglobin (HbF) expression is a known and heritable disease modifier; high HbF levels are correlated with reduced morbidity and mortality in both diseases. This review...

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PMID: 19344402
DOI: 10.1111/j.1365-2141.2009.07650.x

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