Article
Genetics of fetal hemoglobin in Tanzanian and British patients with sickle cell anemia.
Blood - 27 Jan 2011
Makani Julie, Menzel Stephan, Nkya Siana, Cox Sharon E, Drasar Emma, Soka Deogratius, Komba Albert N, Mgaya Josephine, Rooks Helen, Vasavda Nisha, Fegan Gregory, Newton Charles R, Farrall Martin, Thein Swee Lay
Abstract excerpt
Fetal hemoglobin (HbF, α(2)γ(2)) is a major contributor to the remarkable phenotypic heterogeneity of sickle cell anemia (SCA). Genetic variation at 3 principal loci (HBB cluster on chromosome 11p, HBS1L-MYB region on chromosome 6q, and BCL11A on chromosome 2p) have been shown to influence HbF levels and disease severity in β-thalassemia and SCA. Previous studies in SCA, however, have been restricted to...
Topics
- Adolescent
- Adult
- Anemia, Sickle Cell
- Black People
- Child
- Child, Preschool
- Female
- Fetal Hemoglobin
- Genome-Wide Association Study
- Humans
- Male