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Genetics of fetal hemoglobin in Tanzanian and British patients with sickle cell anemia.

Blood - 27 Jan 2011

Makani Julie, Menzel Stephan, Nkya Siana, Cox Sharon E, Drasar Emma, Soka Deogratius, Komba Albert N, Mgaya Josephine, Rooks Helen, Vasavda Nisha, Fegan Gregory, Newton Charles R, Farrall Martin, Thein Swee Lay

Abstract excerpt

Fetal hemoglobin (HbF, α(2)γ(2)) is a major contributor to the remarkable phenotypic heterogeneity of sickle cell anemia (SCA). Genetic variation at 3 principal loci (HBB cluster on chromosome 11p, HBS1L-MYB region on chromosome 6q, and BCL11A on chromosome 2p) have been shown to influence HbF levels and disease severity in β-thalassemia and SCA. Previous studies in SCA, however, have been restricted to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21068433
DOI: 10.1182/blood-2010-08-302703
PMCID: PMC5555384

Genes

MYB
HBB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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