Article

Fetal hemoglobin levels in sickle cell disease and normal individuals are partially controlled by an X-linked gene located at Xp22.2

1992-08-01

Abstract excerpt

Abstract Fetal hemoglobin (Hb F) production in sickle cell (SS) disease and in normal individuals varies over a 20-fold range and is under genetic control. Previous studies suggested that variant Hb F levels might be controlled by genetic loci separate from the beta-globin complex on chromosome 11. Using microscopic radial immunodiffusion and flow cytometric immunofluorescent assays to determine the percentage of...

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Literature Corpus work: ca378925-45fd-5a43-b134-c07bc2754628
DOI: 10.1182/blood.v80.3.816.816

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