Article
Peptide variants reveal how antibodies recognize major histocompatibility complex class I.
European journal of immunology - 1 Nov 1993
Hogquist K A, Grandea A G, Bevan M J
Abstract excerpt
The T cell receptor (TcR) on CD8+ T lymphocytes recognizes a complex which consists of a major histocompatibility complex (MHC) heavy chain, beta 2-microglobulin (beta 2M), and peptide on the surface of antigen-presenting cells. Mutational analyses have suggested that the TcR recognizes both the alpha 1 and alpha 2 domains of the heavy chain as well as the peptide. In light of this, it is of interest to know to...
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