Article
Alloreactive cytotoxic T lymphocytes recognize epitopes determined by both the alpha helices and beta sheets of the class I peptide binding site.
The Journal of experimental medicine - 1 Mar 1992
Hunt H D, Munitz T I, Pease L R
Abstract excerpt
A chimeric class I glycoprotein was created to investigate the functional contribution of the alpha helices and the beta-pleated sheets in forming the antigen recognition site (ARS) of antigen-presenting molecules. This novel molecule was generated by replacing the DNA sequences encoding the alph...
Topics
- Animals
- Antigen-Presenting Cells
- Base Sequence
- Binding Sites
- Chimera
- Epitopes
- Histocompatibility Antigens Class I
- Isoantigens
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Molecular Sequence Data
- Mutation
- Protein Conformation
- T-Lymphocytes, Cytotoxic