Article
The effect of human beta2-microglobulin on major histocompatibility complex I peptide loading and the engineering of a high affinity variant. Implications for peptide-based vaccines.
The Journal of biological chemistry - 23 Oct 1998
Shields M J, Kubota R, Hodgson W, Jacobson S, Biddison W E, Ribaudo R K
Abstract excerpt
The ability to directly load cell surface major histocompatibility complex (MHC) class I molecules with peptides provides a potentially powerful approach toward the development of vaccines to generate cell-mediated immunity. We demonstrate that exogenous beta2-microglobulin (beta2m) stabilizes hu...
Topics
- Antigen Presentation
- Drug Design
- Genetic Variation
- HLA-A Antigens
- Humans
- Mutagenesis, Site-Directed
- Peptides
- Protein Binding
- Protein Engineering
- T-Lymphocytes, Cytotoxic
- Vaccines