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Article

Influence on antibody recognition of amino acid substitutions in the cleft of HLA-DQ2 molecules. Suggestive evidence of peptide-dependent epitopes.

Human immunology - 1 Oct 1995

Viken H D, Paulsen G, Drover S, Marshall W H, Sollid L M, Gaudernack G, Thorsby E

Abstract excerpt

The purpose of this study was to identify polymorphic residues of DQ2 beta chains which are involved in the epitopes recognized by DQ2-reactive mAbs. Binding studies were performed on a panel of DQ2 mutant cells made by transfection of a DQ (alpha 1*0501, beta 1*0301)-positive B-LCL with DQB1 gen...

Topics

3T3 Cells
Alleles
Amino Acid Sequence
Animals
Antibodies, Monoclonal
Antigen-Antibody Reactions
Cell Line
Epitopes
HLA-DQ Antigens
Humans
Mice
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Conformation

Transfection

Source

Identifiers

PMID: 8847230
DOI: 10.1016/0198-8859(95)00047-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8847230-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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