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Differences in transcription and promoters of Xmrk-1 and Xmrk-2 genes suggest a role for Xmrk-2 in pigment pattern development in the platyfish, Xiphophorus maculatus.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Jun 1994

Woolcock B W, Schmidt B M, Kallman K D, Vielkind J R

Abstract excerpt

Pigment (macromelanophore) patterns in the platyfish Xiphophorus maculatus are due to a complex pigmentary locus; for example, the spotted-dorsal (Sd) fin pattern is due to the Sd locus. In interspecific backcross hybrids with the swordtail X. helleri, the Sd pattern changes into benign or malignant dorsal fin melanoma as a result of hemi- or homozygous loss of a platyfish regulatory (R) gene, the tumor...

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PMID: 7522032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

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Differences in transcription and promoters of Xmrk-1 and Xmrk-2 genes suggest a role for Xmrk-2 in pigment pattern development in the platyfish, Xiphophorus maculatus.PMID 7522032Read ↗

Expression regulation triggers oncogenicity of xmrk alleles in the Xiphophorus melanoma system.Semantic proximity Read ↗

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Transcriptional control analyses of the Xiphophorus melanoma oncogene.Semantic proximity Read ↗

Regulation of CDKN2A/B and Retinoblastoma genes in Xiphophorus melanoma.Semantic proximity Read ↗

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Localization of a CDKN2 gene in linkage group V of Xiphophorus fishes defines it as a candidate for the DIFF tumor suppressor.Semantic proximity Read ↗

The macromelanophore locus and the melanoma oncogene Xmrk are separate genetic entities in the genome of Xiphophorus.Semantic proximity Read ↗

Molecular genetic analysis of the melanoma regulatory locus in Xiphophorus interspecies hybrids.Semantic proximity Read ↗

Melanoma loss-of-function mutants in Xiphophorus caused by Xmrk-oncogene deletion and gene disruption by a transposable element.Semantic proximity Read ↗

Tumor induction and tumor regression in Xiphophorus.Semantic proximity Read ↗

Mate choice for more melanin as a mechanism to maintain a functional oncogene.Semantic proximity Read ↗

Activation of the Xmrk proto-oncogene of Xiphophorus by overexpression and mutational alterations.Semantic proximity Read ↗

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