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Article

Molecular genetic analysis of the melanoma regulatory locus in Xiphophorus interspecies hybrids.

Molecular carcinogenesis - 1 Aug 2017

Lu Yuan, Boswell Mikki, Boswell William, Kneitz Susanne, Hausmann Michael, Klotz Barbara, Regneri Janine, Savage Markita, Amores Angel, Postlethwait John, Warren Wesley, Schartl Manfred, Walter Ronald

Abstract excerpt

Development of spontaneous melanoma in Xiphophorus interspecies backcross hybrid progeny, (X. hellerii × [X. maculatus Jp 163 A × X. hellerii]) is due to Mendelian segregation of a oncogene (xmrk) and a molecularly uncharacterized locus, called R(Diff), on LG5. R(Diff) is thought to suppresses the activity of xmrk in healthy X. maculatus Jp 163 A parental species that rarely develop melanoma. To better understand...

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Identifiers

PMID: 28345808
DOI: 10.1002/mc.22651
PMCID: PMC5767473

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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