Article
Localization of a CDKN2 gene in linkage group V of Xiphophorus fishes defines it as a candidate for the DIFF tumor suppressor.
Genes, chromosomes & cancer - 1 Jul 1998
Kazianis S, Gutbrod H, Nairn R S, McEntire B B, Della Coletta L, Walter R B, Borowsky R L, Woodhead A D, Setlow R B, Schartl M, Morizot D C
Abstract excerpt
The Xiphophorus hybrid melanoma model represents one of the earliest reported cases of genetically regulated tumor susceptibility. Melanoma formation in Xiphophorus hybrids may be explained by the inheritance of two genes: a sex-linked oncogene, Xmrk, and a putative tumor suppressor locus, termed DIFF, located in Linkage Group V (LG V). Several genetic mapping procedures were used to produce a new Xiphophorus LG...
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