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Article

Regulation of CDKN2A/B and Retinoblastoma genes in Xiphophorus melanoma.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP - 1 Feb 2007

Butler Andrew P, Trono David, Coletta Luis Della, Beard Rebecca, Fraijo Rachel, Kazianis Steven, Nairn Rodney S

Abstract excerpt

Xiphophorus interspecies hybrids provide several well-characterized genetic models of melanoma susceptibility. The Xiphophorus CDKN2A/B gene, homologous to mammalian CDKN2A/B cyclin-dependent kinase inhibitors (p16 and p15), is a candidate tumor susceptibility gene in these models. Using real-time PCR and Western blot analysis, we analyzed expression of CDKN2A/B in spontaneous and UV-induced primary melanomas...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 17011832
DOI: 10.1016/j.cbpc.2006.07.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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