Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.

doi:10.1084/jem.20031982

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Article

Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.

The Journal of experimental medicine - 5 Apr 2004

Draenert Rika, Le Gall Sylvie, Pfafferott Katja J, Leslie Alasdair J, Chetty Polan, Brander Christian, Holmes Edward C, Chang Shih-Chung, Feeney Margaret E, Addo Marylyn M, Ruiz Lidia, Ramduth Danni, Jeena Prakash, Altfeld Marcus, Thomas Stephanie, Tang Yanhua, Verrill Cori L, Dixon Catherine, Prado Julia G, Kiepiela Photini, Martinez-Picado Javier, Walker Bruce D, Goulder Philip J R

Abstract excerpt

Mutations within cytotoxic T lymphocyte (CTL) epitopes impair T cell recognition, but escape mutations arising in flanking regions that alter antigen processing have not been defined in natural human infections. In human histocompatibility leukocyte antigen (HLA)-B57+ HIV-infected persons, immune selection pressure leads to a mutation from alanine to proline at Gag residue 146 immediately preceding the NH2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15067030
DOI: 10.1084/jem.20031982
PMCID: PMC2211885

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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