Article
The antiviral efficacy of HIV-specific CD8⁺ T-cells to a conserved epitope is heavily dependent on the infecting HIV-1 isolate.
PLoS pathogens - 1 May 2011
Ranasinghe Srinika R F, Kramer Holger B, Wright Cynthia, Kessler Benedikt M, di Gleria Katalin, Zhang Yonghong, Gillespie Geraldine M, Blais Marie-Eve, Culshaw Abigail, Pichulik Tica, Simmons Alison, Rowland-Jones Sarah L, McMichael Andrew J, Dong Tao
Abstract excerpt
A major challenge to developing a successful HIV vaccine is the vast diversity of viral sequences, yet it is generally assumed that an epitope conserved between different strains will be recognised by responding T-cells. We examined whether an invariant HLA-B8 restricted Nef₉₀₋₉₇ epitope FL8 shared between five high titre viruses and eight recombinant vaccinia viruses expressing Nef from different viral isolates...
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