Article
Cell-type-specific consequences of nucleotide excision repair deficiencies: Embryonic stem cells versus fibroblasts.
DNA repair - 1 Oct 2008
de Waard Harm, Sonneveld Edwin, de Wit Jan, Esveldt-van Lange Rebecca, Hoeijmakers Jan H J, Vrieling Harry, van der Horst Gijsbertus T J
Abstract excerpt
Pluripotent embryonic stem cells (ES cells) are the precursors of all different cell types comprising the organism. Since persistent DNA damage in this cell type might lead to mutations that cause huge malformations in the developing organism, genome caretaking is of prime importance. We first compared the sensitivity of wild type mouse embryonic fibroblasts (MEFs) and ES cells for various genotoxic agents and...
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