Article
Factors influencing the repair of the mutagenic lesion O6-methylguanine in DNA by human O6-methylguanine-DNA methyltransferase.
Journal of molecular biology - 20 Jun 1993
Liem L K, Wong C W, Lim A, Li B F
Abstract excerpt
Oligodeoxynucleotides of various chain lengths (p(Bp)nB, n < or = 9) and the eight possible dinucleotide phosphates (pm6GpB and pBpm6G), each containing a single O6-methylguanine residue (m6G), were used to study the repair kinetics of this lesion by the cloned DNA repair proteins; human 21 kDa O...
Topics
- Bacterial Proteins
- Base Sequence
- Chromatography
- DNA Repair
- Escherichia coli Proteins
- Guanine
- Humans
- Kinetics
- Methyltransferases
- Molecular Sequence Data
- Mutation
- O(6)-Methylguanine-DNA Methyltransferase
- Oligodeoxyribonucleotides
- Recombinant Fusion Proteins
- Recombinant Proteins
- Substrate Specificity
- Transcription Factors