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Article

Replication past O(6)-methylguanine by yeast and human DNA polymerase eta.

Molecular and cellular biology - 1 Nov 2000

Haracska L, Prakash S, Prakash L

Abstract excerpt

O(6)-Methylguanine (m6G) is formed by the action of alkylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) on DNA. m6G is a highly mutagenic and carcinogenic lesion, and it presents a block to synthesis by DNA polymerases. Here, we provide genetic and biochemical evidence for the involvement of yeast and human DNA polymerase eta (Poleta) in the replicative bypass of m6G lesions in DNA. The...

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Identifiers

PMID: 11027270
DOI: 10.1128/MCB.20.21.8001-8007.2000
PMCID: PMC86410

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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