Article
Genetic evidence for the involvement of mismatch repair proteins, PMS2 and MLH3, in a late step of homologous recombination.
The Journal of biological chemistry - 18 Dec 2020
Rahman Md Maminur, Mohiuddin Mohiuddin, Shamima Keka Islam, Yamada Kousei, Tsuda Masataka, Sasanuma Hiroyuki, Andreani Jessica, Guerois Raphael, Borde Valerie, Charbonnier Jean-Baptiste, Takeda Shunichi
Abstract excerpt
Homologous recombination (HR) repairs DNA double-strand breaks using intact homologous sequences as template DNA. Broken DNA and intact homologous sequences form joint molecules (JMs), including Holliday junctions (HJs), as HR intermediates. HJs are resolved to form crossover and noncrossover products. A mismatch repair factor, MLH3 endonuclease, produces the majority of crossovers during meiotic HR, but it...
Topics
- Camptothecin
- Cell Line
- DNA Breaks, Double-Stranded
- DNA Repair
- DNA, Cruciform
- G2 Phase
- Gamma Rays
- Homologous Recombination
- Humans
- Mismatch Repair Endonuclease PMS2
- MutL Proteins
- Mutation
- Phthalazines