Article
The mutational spectrum of the HPRT gene from human T cells in vivo shares a significant concordant set of hot spots with MNNG-treated human cells.
Cancer research - 15 Sept 2003
Tomita-Mitchell Aoy, Ling Losee Lucy, Glover Curtis L, Goodluck-Griffith Jacklene, Thilly William G
Abstract excerpt
The preponderance of G:C to A:T transitions in inherited and somatic human mutations has led to the hypothesis that some of these mutations arise as a result of formation of O(6)-methylguanine in DNA. To test this hypothesis, the fine structure map of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced mutations was determined in human lymphoblastoid cells in the human...
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