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Article

MGMT: a personal perspective.

DNA repair - 1 Aug 2007

Mitra Sankar

Abstract excerpt

This review describes the history of studies on alkylation damage of mammalian genomes and its carcinogenic consequences that led to the discovery of a unique DNA repair protein, named MGMT. MGMT repairs O(6)-alkylguanine, a critical mutagenic lesion induced by alkylating agents. The follow-up studies in mammalian cells following the discovery of the ubiquitous repair protein in E. coli are summarized.

Topics

Alkylating Agents
Animals
Cloning, Molecular
DNA Modification Methylases
DNA Repair
DNA Repair Enzymes
Escherichia coli
Guanine
History, 20th Century
History, 21st Century
Humans
Methylnitronitrosoguanidine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

O(6)-Methylguanine-DNA Methyltransferase

Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 17482889
DOI: 10.1016/j.dnarep.2007.03.007
PMCID: PMC2692271

Genes

MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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