Article
Contribution of O6-alkylguanine and N-alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: new insights gained from studies of genetically engineered mammalian cell lines.
Environmental and molecular mutagenesis - 1 Jan 1993
Kaina B, Fritz G, Coquerelle T
Abstract excerpt
O6-methyl- and O6-ethylguanine are the major premutagenic and precarcinogenic lesions induced in DNA by monofunctional alkylating agents, albeit formed in minor amounts. The involvement of these lesions in SCE and aberration formation is less clear. We have analyzed the contribution of O6-alkylguanine to SCE and aberration formation, as well as its toxic and point mutation inducing effect in transgenic Chinese...
Topics
- Alkylation
- Animals
- Cell Line
- Chromosome Aberrations
- DNA
- Methyltransferases
- Models, Genetic
- Mutation
- O(6)-Methylguanine-DNA Methyltransferase
- Sister Chromatid Exchange