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Article

The rate of hydrolytic deamination of 5-methylcytosine in double-stranded DNA.

Nucleic acids research - 25 Mar 1994

Shen J C, Rideout W M, Jones P A

Abstract excerpt

The modified base, 5-methylcytosine, constitutes approximately 1% of human DNA, but sites containing 5-methylcytosine account for at least 30% of all germline and somatic point mutations. A genetic assay with a sensitivity of 1 in 10(7), based on reversion to neomycin resistance of a mutant pSV2-neo plasmid, was utilized to determine and compare the deamination rates of 5-methylcytosine and cytosine in...

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Identifiers

PMID: 8152929
DOI: 10.1093/nar/22.6.972
PMCID: PMC307917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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