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Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions.

Nucleic acids research - 18 Nov 2021

Yu Dan, Horton John R, Yang Jie, Hajian Taraneh, Vedadi Masoud, Sagum Cari A, Bedford Mark T, Blumenthal Robert M, Zhang Xing, Cheng Xiaodong

Abstract excerpt

MettL3-MettL14 methyltransferase complex has been studied widely for its role in RNA adenine methylation. This complex is also recruited to UV- and X-ray exposed DNA damaged sites, and its methyltransfer activity is required for subsequent DNA repair, though in theory this could result from RNA methylation of short transcripts made at the site of damage. We report here that MettL3-MettL14 is active in vitro on...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 34086966
DOI: 10.1093/nar/gkab460
PMCID: PMC8599731

Genes

YTHDC1
FEN1
GEN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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