Article
Hepatitis B virus-associated multistep hepatocarcinogenesis: a stepwise increase in allelic alterations.
Cancer research - 15 Jul 2008
Lee Joyce Man-Fong, Wong Chun-Ming, Ng Irene Oi-Lin
Abstract excerpt
Hepatocarcinogenesis is a multistep process, but systematic analysis using a genetic or molecular approach to accurately delineate the different stages of hepatocellular carcinoma (HCC) development is scarce. In this study, we used genome-wide allelotyping to systematically evaluate the allelic alterations in the multisteps of hepatitis B virus-associated hepatocarcinogenesis. The overall fractional allelic loss...
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