Article
Genetic alternations of p73 are infrequent but may occur in early stage hepatocellular carcinoma.
Anticancer research - 1 Jan 2000
Peng C Y, Tsai S L, Yeh C T, Hung S P, Chen M F, Chen T C, Chu C M, Liaw Y F
Abstract excerpt
p73, a structural homologue of the tumor suppressor gene, p53, has recently been identified and mapped to chromosome 1p36, where genomic loss of heterozygosity (LOH) often occurs in human hepatocellular carcinoma (HCC). To determine whether p73 is involved in the development of HCC and whether there is an inverse correlation between the mutations of p73 and p53, we examined 22 paired tumors/noncancerous liver...
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