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Article

Lymphadenopathy induced by the cooperation between lprcg and gld genes is of lpr but not of gld phenotype.

European journal of immunology - 1 Jul 1994

Matsuzawa A, Katagiri T, Ogata Y, Kominami R, Kimura M

Abstract excerpt

Mice homozygous for the lpr (lymphoproliferation), lprcg or gld (generalized lymphoproliferative disease) mutation develop strikingly similar lymphadenopathy with expansion of B220+ CD4- CD8- double-negative (DN) T cells and autoimmunity. To elucidate the roles of bone marrow (BM) and lymph node...

Topics

Animals
Bone Marrow Transplantation
Female
Genotype
Lymph Nodes
Lymphatic Diseases
Male
Mice
Mice, Inbred C3H
Mice, Inbred CBA
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8026532
DOI: 10.1002/eji.1830240740

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8026532-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Lymphadenopathy induced by the cooperation between lprcg and gld genes is of lpr but not of gld phenotype.PMID 8026532Read ↗

A new allele of the lpr locus, lprcg, that complements the gld gene in induction of lymphadenopathy in the mouse.Semantic proximity Read ↗

Haematopoietic cell transfers between C57BL/6 mice differing at the lpr or gld locus.Semantic proximity Read ↗

Genotype-restricted lymphoproliferation in autoimmune lpr mice.Semantic proximity Read ↗

The Yaa mutation induces the development of autoimmunity in mice heterozygous for the gld (generalized lymphadenopathy disease) mutation.Semantic proximity Read ↗

Autoimmunity in mice bearing lprcg: a novel mutant gene.Semantic proximity Read ↗

lpr And gld: Single Gene Models Of Systemic Autoimmunity And Lymphoproliferative DiseaseSemantic proximity Read ↗

<i>Lpr</i> and <i>gld</i>: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative DiseaseSemantic proximity Read ↗

Differences defined by bone marrow transplantation suggest that lpr and gld are mutations of genes encoding an interacting pair of molecules.Semantic proximity Read ↗

Correction of gld autoimmunity by co-infusion of normal bone marrow suggests that gld is a mutation of the Fas ligand gene.Semantic proximity Read ↗

Distinctive expression of lprcg in the heterozygous state on different genetic backgrounds.Semantic proximity Read ↗

Tetraparental mice reveal complex cellular interactions of the mutant, autoimmunity-inducing lpr gene.Semantic proximity Read ↗

Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice.Semantic proximity Read ↗

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