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Article

Lymphadenopathy induced by the cooperation between lprcg and gld genes is of lpr but not of gld phenotype.

European journal of immunology - 1 Jul 1994

Matsuzawa A, Katagiri T, Ogata Y, Kominami R, Kimura M

Abstract excerpt

Mice homozygous for the lpr (lymphoproliferation), lprcg or gld (generalized lymphoproliferative disease) mutation develop strikingly similar lymphadenopathy with expansion of B220+ CD4- CD8- double-negative (DN) T cells and autoimmunity. To elucidate the roles of bone marrow (BM) and lymph node (LN) in lymphoproliferation, BM and LN were transplanted simultaneously into normal or +/+ mice in various genotype...

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PMID: 8026532
DOI: 10.1002/eji.1830240740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Lymphadenopathy induced by the cooperation between lprcg and gld genes is of lpr but not of gld phenotype.PMID 8026532Read ↗

A new allele of the lpr locus, lprcg, that complements the gld gene in induction of lymphadenopathy in the mouse.Semantic proximity Read ↗

Haematopoietic cell transfers between C57BL/6 mice differing at the lpr or gld locus.Semantic proximity Read ↗

Genotype-restricted lymphoproliferation in autoimmune lpr mice.Semantic proximity Read ↗

The Yaa mutation induces the development of autoimmunity in mice heterozygous for the gld (generalized lymphadenopathy disease) mutation.Semantic proximity Read ↗

Autoimmunity in mice bearing lprcg: a novel mutant gene.Semantic proximity Read ↗

lpr And gld: Single Gene Models Of Systemic Autoimmunity And Lymphoproliferative DiseaseSemantic proximity Read ↗

<i>Lpr</i> and <i>gld</i>: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative DiseaseSemantic proximity Read ↗

Differences defined by bone marrow transplantation suggest that lpr and gld are mutations of genes encoding an interacting pair of molecules.Semantic proximity Read ↗

Correction of gld autoimmunity by co-infusion of normal bone marrow suggests that gld is a mutation of the Fas ligand gene.Semantic proximity Read ↗

Distinctive expression of lprcg in the heterozygous state on different genetic backgrounds.Semantic proximity Read ↗

Tetraparental mice reveal complex cellular interactions of the mutant, autoimmunity-inducing lpr gene.Semantic proximity Read ↗

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