Article
The lpr and gld genes in systemic autoimmunity: life and death in the Fas lane.
Immunology today - 1 Nov 1992
Cohen P L, Eisenberg R A
Abstract excerpt
The single gene lpr and gld models of spontaneous systemic autoimmunity have attracted much attention in recent years. Here, Philip Cohen and Robert Eisenberg describe the fascinating recent findings that the lpr and gld [corrected] phenotypes result from defects in the Fas gene and, perhaps, in...
Topics
- Animals
- Antigens, Surface
- Apoptosis
- Autoimmune Diseases
- Autoimmunity
- B-Lymphocytes
- Disease Models, Animal
- Genes
- Immune Tolerance
- Ligands
- Lupus Erythematosus, Systemic
- Lymphoproliferative Disorders
- Membrane Proteins
- Mice
- Mice, Mutant Strains
- Phenotype
- Radiation Chimera
- T-Lymphocyte Subsets