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Article

Loss of NF1 alleles distinguish sporadic from NF1-associated pilocytic astrocytomas.

Journal of neuropathology and experimental neurology - 1 Sept 2001

Kluwe L, Hagel C, Tatagiba M, Thomas S, Stavrou D, Ostertag H, von Deimling A, Mautner V F

Abstract excerpt

Pilocytic astrocytomas classified as WHO grade I typically arise in childhood and upon complete surgical removal carry a favorable prognosis. Children with neurofibromatosis 1 (NF1) have a vastly increased risk for pilocytic astrocytomas, especially for those of the optic nerve. Using 4 intragenic NF1 microsatellite markers, we examined losses of NF1 alleles on the long arm of chromosome 17 in 12 NF1-associated...

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Identifiers

PMID: 11556548
DOI: 10.1093/jnen/60.9.917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of NF1 alleles distinguish sporadic from NF1-associated pilocytic astrocytomas.PMID 11556548Read ↗

Loss of neurofibromatosis 1 (<i>NF1</i>) gene expression in NF1‐associated pilocytic astrocytomasSemantic proximity Read ↗

Mutational and expression analysis of the NF1 gene argues against a role as tumor suppressor in sporadic pilocytic astrocytomas.Semantic proximity Read ↗

Deletions on the long arm of chromosome 17 in pilocytic astrocytoma.Semantic proximity Read ↗

Somatic neurofibromatosis type 1 (NF1) inactivation characterizes NF1-associated pilocytic astrocytoma.Semantic proximity Read ↗

Cancer-related gene expression profiles in NF1-associated pilocytic astrocytomasSemantic proximity Read ↗

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Molecular and cytogenetic analysis of tumors in von Recklinghausen neurofibromatosis.Semantic proximity Read ↗

Loss of NF1 allele in Schwann cells but not in fibroblasts derived from an NF1-associated neurofibroma.Semantic proximity Read ↗

Pilocytic astrocytomas do not show most of the genetic changes commonly seen in diffuse astrocytomas.Semantic proximity Read ↗

Biallelic inactivation of NF1 in a sporadic plexiform neurofibroma.Semantic proximity Read ↗

Molecular analysis of astrocytomas presenting after age 10 in individuals with NF1.Semantic proximity Read ↗

TP53 mutations are frequent in malignant NF1 tumors.Semantic proximity Read ↗

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