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Article

Phenotypic determinants of adenovirus E1A gene autoregulation: variable region between conserved coding domains 2 and 3.

Virology - 10 Nov 1995

Hamid R, Cogan J D, Jones S N, Tibbetts C

Abstract excerpt

Different serotypes and evolutionary variants of human adenoviruses exhibit distinctive patterns of positive and negative autoregulation of the viral E1A gene. An autoregulatory E1A promoter mutation of the adenovirus type 3 (Ad3) E1A gene renders Ad3hr15 incapable of growth in normally permissive cells. The promoter mutation is complemented in trans by E1A products of the heterologous helper adenovirus type 5...

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Identifiers

PMID: 7491791
DOI: 10.1006/viro.1995.0039

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