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Article

Differential Splicing of Human Adenovirus 5 E1A RNA Expressed in cis versus in trans.

Journal of virology - 24 Feb 2021

Graves Drayson, Akkerman Nikolas, Bachus Scott, Pelka Peter

Abstract excerpt

Human adenovirus (HAdV) is used extensively as a vector for gene delivery for a variety of purposes, including gene therapy and vaccine development. Most adenoviral vectors used for these approaches have a deletion of early region 1 (E1), which is complemented by the cell line. Most commonly, these are 293 cells for HAdV serotype 2 or 5. The 293 cells have the left end of HAdV5 integrated into chromosome 19 and...

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Source

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Identifiers

PMID: 33361423
DOI: 10.1128/JVI.02081-20
PMCID: PMC8094950

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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