Article
Differential effects of the adenovirus E1A oncogene on members of the AP-1 transcription factor family.
Molecular and cellular biology - 1 Nov 1990
van Dam H, Offringa R, Meijer I, Stein B, Smits A M, Herrlich P, Bos J L, van der Eb A J
Abstract excerpt
The adenovirus early region 1A (E1A) oncogene interferes with the expression level and activity of the AP-1 transcription factor family. E1A abolished the transactivating function of AP-1 (Jun/Fos), which binds to the 12-O-tetradecanoylphorbol-13-acetate-responsive element of the collagenase gene (collTRE). In contrast, the activity of another member of the AP-1 family that binds to the c-junTRE was not...
Topics
- Adenovirus Early Proteins
- Adenoviruses, Human
- Animals
- Cell Line
- Cell Transformation, Neoplastic
- DNA-Binding Proteins
- Humans
- Mutation
- Oncogene Proteins, Viral
- Oncogenes
- Polyomavirus