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Article

Complementary functions of E1a conserved region 1 cooperate with conserved region 3 to activate adenovirus serotype 5 early promoters.

Journal of virology - 1 Aug 1994

Wong H K, Ziff E B

Abstract excerpt

The amino-terminal region of the adenovirus type 5 E1a protein including conserved regions (CRs) 1 and 2 binds the 105-kDa retinoblastoma protein and a second, 300-kDa, cellular protein. We show that mutant viruses with deletions of CR1 which release the binding of either p105 or p300 still activate early promoters and infect cells productively. However, mutations which disrupt binding of both proteins disrupt...

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Identifiers

PMID: 8035489
DOI: 10.1128/JVI.68.8.4910-4920.1994
PMCID: PMC236431

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Complementary functions of E1a conserved region 1 cooperate with conserved region 3 to activate adenovirus serotype 5 early promoters.PMID 8035489Read ↗

Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growthSemantic proximity Read ↗

The transcriptional co-activator proteins p300 and CBP stimulate adenovirus E1A conserved region 1 transactivation independent of a direct interaction.Semantic proximity Read ↗

Transcriptional control by adenovirus E1A conserved region 3 via p300/CBP.Semantic proximity Read ↗

CBF mediates adenovirus Ela trans-activation by interaction at the C-terminal promoter targeting domain of conserved region 3.Semantic proximity Read ↗

Comparative Sequence Analysis of the Largest E1A Proteins of Human and Simian AdenovirusesSemantic proximity Read ↗

Human adenovirus type 5 vectors deleted of early region 1 (E1) undergo limited expression of early replicative E2 proteins and DNA replication in non-permissive cellsSemantic proximity Read ↗

Molecular regulation and biological function of adenovirus early genes: the E4 ORFsSemantic proximity Read ↗

Conserved region 2 of adenovirus E1A has a function distinct from pRb binding required to prevent cell cycle arrest by p16INK4a or p27Kip1.Semantic proximity Read ↗

Analysis of E1A-mediated growth regulation functions: binding of the 300-kilodalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activity.Semantic proximity Read ↗

Identification of a second CtBP binding site in adenovirus type 5 E1A conserved region 3.Semantic proximity Read ↗

Functional interactions within adenovirus E1A protein complexes.Semantic proximity Read ↗

The N-terminal region of the adenovirus type 5 E1A proteins can repress expression of cellular genes via two distinct but overlapping domains.Semantic proximity Read ↗

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