Article
Complementary functions of E1a conserved region 1 cooperate with conserved region 3 to activate adenovirus serotype 5 early promoters.
Journal of virology - 1 Aug 1994
Wong H K, Ziff E B
Abstract excerpt
The amino-terminal region of the adenovirus type 5 E1a protein including conserved regions (CRs) 1 and 2 binds the 105-kDa retinoblastoma protein and a second, 300-kDa, cellular protein. We show that mutant viruses with deletions of CR1 which release the binding of either p105 or p300 still activ...
Topics
- 3T3 Cells
- Adenoviridae
- Adenovirus E1A Proteins
- Animals
- Cell Line
- Conserved Sequence
- Diploidy
- E1A-Associated p300 Protein
- Fibroblasts
- Gene Expression Regulation, Viral
- Genetic Complementation Test
- Humans
- Mice
- Mutation
- Nuclear Proteins
- Promoter Regions, Genetic
- Retinoblastoma Protein
- Sequence Deletion