Article
Transcriptional control by adenovirus E1A conserved region 3 via p300/CBP.
Nucleic acids research - 1 Mar 2009
Pelka Peter, Ablack Jailal N G, Torchia Joseph, Turnell Andrew S, Grand Roger J A, Mymryk Joe S
Abstract excerpt
The human adenovirus type 5 (HAdV-5) E1A 13S oncoprotein is a potent regulator of gene expression and is used extensively as a model for transcriptional activation. It possesses two independent transcriptional activation domains located in the N-terminus/conserved region (CR) 1 and CR3. The protein acetyltransferase p300 was previously identified by its association with the N-terminus/CR1 portion of E1A and this...
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