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Article

The N-terminal region of the adenovirus type 5 E1A proteins can repress expression of cellular genes via two distinct but overlapping domains.

Journal of virology - 1 May 1995

Dorsman J C, Hagmeyer B M, Veenstra J, Elfferich P, Nabben N, Zantema A, van der Eb A J

Abstract excerpt

The transforming E1A 12S and E1A 13S proteins of human adenovirus type 5 (Ad5) contain two and three conserved regions, respectively. In the present study, the contribution of sequences in the nonconserved N-terminal region of the E1A proteins to morphological transformation and to down-regulation of a number of mitogen-inducible genes was investigated. As described previously, transformation of NRK cells (an...

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Identifiers

PMID: 7707522
DOI: 10.1128/JVI.69.5.2962-2967.1995
PMCID: PMC188995

Genes

NRK

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Source receipt: pubmed, retrieved 7 Sept 2026.

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The N-terminal region of the adenovirus type 5 E1A proteins can repress expression of cellular genes via two distinct but overlapping domains.PMID 7707522Read ↗

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