The N-terminal region of the adenovirus type 5 E1A proteins can repress expression of cellular genes via two distinct but overlapping domains.

doi:10.1128/JVI.69.5.2962-2967.1995

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Article

The N-terminal region of the adenovirus type 5 E1A proteins can repress expression of cellular genes via two distinct but overlapping domains.

Journal of virology - 1 May 1995

Dorsman J C, Hagmeyer B M, Veenstra J, Elfferich P, Nabben N, Zantema A, van der Eb A J

Abstract excerpt

The transforming E1A 12S and E1A 13S proteins of human adenovirus type 5 (Ad5) contain two and three conserved regions, respectively. In the present study, the contribution of sequences in the nonconserved N-terminal region of the E1A proteins to morphological transformation and to down-regulation of a number of mitogen-inducible genes was investigated. As described previously, transformation of NRK cells (an...

Topics

Adenovirus E1A Proteins
Adenoviruses, Human
Amino Acid Sequence
Animals
Cell Line
Collagenases
Conserved Sequence
Cyclin D1
Cyclins
Down-Regulation
Gene Expression Regulation, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Viral

HeLa Cells

Humans

Molecular Sequence Data

Mutation

Oncogene Proteins

Rats

Source

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Identifiers

PMID: 7707522
DOI: 10.1128/JVI.69.5.2962-2967.1995
PMCID: PMC188995

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7707522-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The N-terminal region of the adenovirus type 5 E1A proteins can repress expression of cellular genes via two distinct but overlapping domains.PMID 7707522Read ↗

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