Article
Discrete domains of human U6 snRNA required for the assembly of U4/U6 snRNP and splicing complexes.
The EMBO journal - 1 Jan 1990
Bindereif A, Wolff T, Green M R
Abstract excerpt
U6 snRNA sequences required for assembly of U4/U6 snRNP and splicing complexes were determined by in vitro reconstitution of snRNPs. Both mutagenesis and chemical modification/interference assays identify a U6 snRNA domain required for U4/U6 snRNP formation. The results support the existence of a...
Topics
- Base Sequence
- Binding Sites
- Chemical Phenomena
- Chemistry
- Immunosorbent Techniques
- Molecular Sequence Data
- Molecular Weight
- Mutation
- Nucleic Acid Conformation
- RNA Splicing
- RNA, Small Nuclear
- Ribonucleoproteins
- Ribonucleoproteins, Small Nuclear
- Structure-Activity Relationship
- Transcription, Genetic