Glutathione s-transferase genotypes as risk factors for head and neck cancer.

doi:10.1016/s0002-9610(99)80339-0

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Article

Glutathione s-transferase genotypes as risk factors for head and neck cancer.

American journal of surgery - 1 Nov 1995

Trizna Z, Clayman G L, Spitz M R, Briggs K L, Goepfert H

Abstract excerpt

BACKGROUND: Several enzymatic systems, including glutathione S-transferases, are involved in the metabolism of environmental agents. The absence of glutathione S-transferases mu (GSTM1) and theta (GSTT1) results in decreased detoxification of carcinogens, for example, chemicals in cigarette smoke. These metabolic deficiencies may predispose individuals to the development of smoking-related tumors, such as cancers...

Topics

Base Composition
Carcinogens
Carcinoma, Squamous Cell
Case-Control Studies
DNA
DNA, Neoplasm
Female
Genome
Genotype
Glutathione Transferase
Head and Neck Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Laryngeal Neoplasms

Lymphocytes

Male

Mouth Neoplasms

Odds Ratio

Pharyngeal Neoplasms

Source

Open in PubMed

Identifiers

PMID: 7485742
DOI: 10.1016/s0002-9610(99)80339-0

Genes

GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7485742-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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