Gene polymorphisms in detoxification enzymes as susceptibility factor for head and neck cancer?

doi:10.1016/S0194-59980300176-1

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Gene polymorphisms in detoxification enzymes as susceptibility factor for head and neck cancer?

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery - 1 May 2003

Gronau S, Koenig-Greger D, Jerg M, Riechelmann H

Abstract excerpt

OBJECTIVE: Impaired detoxification of carcinogens found in tobacco smoke appears to increase the risk for tobacco associated cancer. The objective of this study was to investigate concomitant polymorphisms in genes encoding for various detoxification enzymes in patients with head and neck squamous cell carcinoma (HNSCC). METHODS: In 187 patients with HNSCC and in 139 healthy control subjects, the polymorphisms of...

Topics

Aged
Alcohol-Related Disorders
Aryl Hydrocarbon Hydroxylases
Carcinoma, Squamous Cell
Cytochrome P-450 CYP1A1
Cytochrome P-450 CYP2D6
Female
Genetic Predisposition to Disease
Genotype
Glutathione Transferase
Head and Neck Neoplasms
Humans
Inactivation, Metabolic

Source

Open in PubMed

Identifiers

PMID: 12748560
DOI: 10.1016/S0194-59980300176-1

Genes

GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Polymorphism, Genetic

Tobacco Use Disorder