Article
Glutathione S-transferase GSTM1, GSTM3, GSTP1 and GSTT1 genotypes and the risk of smoking-related oral and pharyngeal cancers.
International journal of cancer - 31 Mar 1999
Jourenkova-Mironova N, Voho A, Bouchardy C, Wikman H, Dayer P, Benhamou S, Hirvonen A
Abstract excerpt
Several polymorphic glutathione S-transferase enzymes are involved in the detoxification of active metabolites of many potential carcinogens from tobacco smoke and may therefore be important in modulating susceptibility to smoking-related cancers. As part of a hospital-based case-control study performed in France among Caucasian smokers, we studied GSTM1, GSTM3, GSTP1 and GSTT1 gene polymorphisms in 121 patients...
Topics
- Adult
- Female
- Genotype
- Glutathione Transferase
- Humans
- Male
- Middle Aged
- Mouth Neoplasms
- Pharyngeal Neoplasms
- Polymorphism, Genetic
- Risk Factors
- Smoking