Article
[GSTM1 gene polymorphism in patients with head and neck tumors].
Laryngo- rhino- otologie - 1 Jun 2000
Gronau S, König-Greger D, Rettinger G, Riechelmann H
Abstract excerpt
BACKGROUND: Glutathione S-Transferase mu (GSTM) is a phase II detoxification enzyme, which rapidly detoxifies carcinogens found in tobacco smoke. The prevalence of this polymorphism is about 50% in the caucasian population. The lack of GSTM1 has been linked with an increased susceptibility of smoking related cancers. A homozygote deletion of the GSTM-gene results in a missing gene product. The objective of this...
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