Genetic polymorphisms of smoking-related carcinogen detoxifying enzymes and head and neck cancer susceptibility.

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Article

Genetic polymorphisms of smoking-related carcinogen detoxifying enzymes and head and neck cancer susceptibility.

Anticancer research - 1 Feb 2009

Lacko Martin, Oude Ophuis Michael B, Peters Wilbert H M, Manni Johannes J

Abstract excerpt

Smoking and the consumption of alcohol are the main risk factors for head and neck cancer. However, interindividual variation in the activity of enzymes involved in the detoxification of tobacco smoke (pro)carcinogens, such as microsomal epoxide hydrolase (mEH), glutathione-S-transferases (GSTs) and uridine 5'-diphosphate (UDP)-glucuronosyltransferase (UGTs), may influence the process of carcinogenesis. Genetic...

Topics

Carcinogens
Carcinoma, Squamous Cell
Epoxide Hydrolases
Genetic Predisposition to Disease
Glucuronosyltransferase
Glutathione Transferase
Head and Neck Neoplasms
Humans
Inactivation, Metabolic
Polymorphism, Genetic
Smoking

Source

Open in PubMed

Identifiers

PMID: 19331232

Genes

GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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