Article
Polymorphisms of the glutathione S-transferase P1 gene and head and neck cancer susceptibility.
Head & neck - 1 Jan 2003
Oude Ophuis Michael B, Roelofs Hennie M J, van den Brandt Piet A, Peters Wilbert H M, Manni Johannes J
Abstract excerpt
BACKGROUND: Factors determining the individual susceptibility to head and neck squamous cell carcinoma (HNSCC) are still largely unknown. An imbalance between enzymes involved in the toxification and detoxification of (pre)-carcinogens closely related to HNSCC, which may appear during smoking and alcohol consumption, may play a role. Genetic polymorphisms in glutathione S-transferases (GSTs) often result in...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alcohol Drinking
- Biomarkers, Tumor
- Carcinoma, Squamous Cell
- Case-Control Studies
- Female
- Genetic Predisposition to Disease
- Genotype
- Glutathione Transferase
- Head and Neck Neoplasms
- Humans
- Logistic Models
- Male
- Middle Aged
- Multivariate Analysis
- Odds Ratio