Article
Inclusion of unaffected sibs increases power in model-free linkage analysis of a behavioral trait.
BMC genetics - 30 Dec 2005
Plancoulaine Sabine, Alcaïs Alexandre, Chen Yue, Abel Laurent, Gagnon France
Abstract excerpt
Study design strategies are of critical importance in the search for genes underlying complex diseases. Two important design choices in planning gene mapping studies are the analytic strategy to be used, which will have an impact on the type of data to be collected, and the choice of genetic markers. In the present paper, we used the simulated behavioral trait data provided in the Genetic Analysis Workshop 14 to:...
Topics
- Behavior
- Chromosome Mapping
- Humans
- Lod Score
- Microsatellite Repeats
- Models, Genetic
- Polymorphism, Single Nucleotide
- Quantitative Trait, Heritable
- Siblings