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Article

Further investigation of linkage disequilibrium SNPs and their ability to identify associated susceptibility loci.

Annals of human genetics - 1 May 2004

North B V, Curtis D, Martin E R, Lai E H, Roses A D, Sham P C

Abstract excerpt

There is currently considerable interest in the use of single-nucleotide polymorphisms (SNPs) to map disease susceptibility genes. The success of this method will depend on a number of factors including the strength of linkage disequilibrium (LD) between marker and disease loci. We used a data set of SNP genotypings in the region of the APOE disease susceptibility locus to investigate the likely usefulness of...

Topics

Alzheimer Disease
Case-Control Studies
Gene Frequency
Genetic Markers
Genetic Predisposition to Disease
Genetics, Population
Haplotypes
Humans
Likelihood Functions
Linkage Disequilibrium
Models, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 15180704
DOI: 10.1046/j.1529-8817.2004.00086.x

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15180704-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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