Power calculations for a general class of tests of linkage and association that use nuclear families with affected and unaffected sibs.

doi:10.1006/tpbi.2001.1541

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Article

Power calculations for a general class of tests of linkage and association that use nuclear families with affected and unaffected sibs.

Theoretical population biology - 1 Nov 2001

Kaplan N L, Martin E R

Abstract excerpt

Family-based tests of association are now often used when trying to fine-map a disease susceptibility locus. Recently, several tests of linkage and association have been proposed that use nuclear families with multiple affected and unaffected sibs rather than just case-parent triads. In this paper we propose a test that generalizes these previous tests. Formulae are derived to calculate the power of the test for...

Topics

Alleles
Chromosome Mapping
Genetic Diseases, Inborn
Genetic Markers
Genetic Predisposition to Disease
Haplotypes
Humans
Linkage Disequilibrium
Models, Genetic
Nuclear Family

Source

Open in PubMed

Identifiers

PMID: 11855953
DOI: 10.1006/tpbi.2001.1541

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