On the advantage of haplotype analysis in the presence of multiple disease susceptibility alleles.

doi:10.1002/gepi.10200

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Article

On the advantage of haplotype analysis in the presence of multiple disease susceptibility alleles.

Genetic epidemiology - 1 Oct 2002

Morris Richard W, Kaplan Norman L

Abstract excerpt

We investigated the effect of multiple susceptibility alleles at a single disease locus on the statistical power of a likelihood ratio test to detect association between alleles at a marker locus and a disease phenotype in a case-control design. Using simplifying assumptions to obtain the joint f...

Topics

Alleles
Case-Control Studies
Chromosome Mapping
Gene Frequency
Genetic Diseases, Inborn
Genetic Markers
Genetic Predisposition to Disease
Genetic Testing
Haplotypes
Humans
Likelihood Functions
Linkage Disequilibrium
Polymorphism, Single Nucleotide
Reproducibility of Results
Risk Assessment

Source

Open in PubMed

Identifiers

PMID: 12384975
DOI: 10.1002/gepi.10200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-12384975-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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