Article
Antisense inhibition of engrailed genes in mouse embryos reveals roles for these genes in craniofacial and neural tube development.
Teratology - 1 May 1995
Augustine K A, Liu E T, Sadler T W
Abstract excerpt
The roles of engrailed-1 (En-1) and engrailed-2 (En-2) have been investigated during gastrulation and neurulation in mouse embryos. Using antisense oligonucleotides and murine whole embryo culture, early somite embryos were injected with antisense phosphorothioated oligonucleotides directed again...
Topics
- Animals
- Base Sequence
- Culture Techniques
- Embryo, Mammalian
- Embryonic and Fetal Development
- Facial Bones
- Female
- Gastrula
- Genes, Homeobox
- Homeodomain Proteins
- Mice
- Mice, Inbred ICR
- Molecular Sequence Data
- Nerve Tissue Proteins
- Nervous System
- Nervous System Malformations
- Oligonucleotides, Antisense
- Phenotype