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Article

Maternal Nanog is required for zebrafish embryo architecture and for cell viability during gastrulation.

Development (Cambridge, England) - 9 Jan 2018

Veil Marina, Schaechtle Melanie Anna, Gao Meijiang, Kirner Viola, Buryanova Lenka, Grethen Rachel, Onichtchouk Daria

Abstract excerpt

Nanog has been implicated in establishment of pluripotency in mammals and in zygotic genome activation in zebrafish. In this study, we characterize the development of MZnanog (maternal and zygotic null) mutant zebrafish embryos. Without functional Nanog, epiboly is severely affected, embryo axes do not form and massive cell death starts at the end of gastrulation. We show that three independent defects in MZnanog...

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Identifiers

PMID: 29180568
DOI: 10.1242/dev.155366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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