Article
Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2.
Science (New York, N.Y.) - 4 Aug 1995
Hanks M, Wurst W, Anson-Cartwright L, Auerbach A B, Joyner A L
Abstract excerpt
The related mouse Engrailed genes En-1 and En-2 are expressed from the one- and approximately five-somite stages, respectively, in a similar presumptive mid-hindbrain domain. However, mutations in En-1 and En-2 produce different phenotypes. En-1 mutant mice die at birth with a large mid-hindbrain deletion, whereas En-2 mutants are viable, with cerebellar defects. To determine whether these contrasting phenotypes...
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