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Spatial and temporal 'knock down' of gene expression by electroporation of double-stranded RNA and morpholinos into early postimplantation mouse embryos.

Mechanisms of development - 1 Oct 2002

Mellitzer Georg, Hallonet Marc, Chen Lan, Ang Siew-Lan

Abstract excerpt

Here we report the use of double-stranded RNA (dsRNA) and morpholino technologies to specifically 'knock down' gene expression in early postimplantation mouse embryos. Sequence specific interference mediated by either dsRNA or by morpholino has been a useful tool for studying gene function in several organisms. However, specifically for the dsRNA, doubts have been raised about whether it could successfully be...

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PMID: 12351170
DOI: 10.1016/s0925-4773(02)00191-0

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