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Article

Functional knockdown of neuropilin-1 in the developing chick nervous system by siRNA hairpins phenocopies genetic ablation in the mouse.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jun 2004

Bron Romke, Eickholt Britta J, Vermeren Matthieu, Fragale Ninfa, Cohen James

Abstract excerpt

The chick embryo is widely used for the study of vertebrate development, but a general, reliable loss-of-function strategy for the analysis of gene function is currently not available. By using small inhibitory hairpin RNA (siRNA) molecules generated by the mouse U6 promoter, we have applied an RNA interference approach to achieve quantitative knockdown of the neuropilin-1 (Nrp-1) receptor in chick embryos....

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Identifiers

PMID: 15162508
DOI: 10.1002/dvdy.20043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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